While it is tempting to grab the points with the primetime home underdog, this is a spot where we are going to opt for the favorite. Simply put, even with some key players out (Deebo Samuel & Trent Williiams), this 49ers team is a force on both sides of the ball. San Francisco has an elite pass rush, and they’ve also been one of the best defenses in the league in pass coverage. When you combine those two metrics against a non-mobile Kirk Cousins, who will be without his top WR (Justin Jefferson), we foresee problems for Minnesota. The one slight vulnerability of the 49ers defense is defending the run, but the Vikings have struggled running the ball all season. We are going to lay the -6.5 points behind a 49ers team who we feel is a full touchdown better than the Vikings. Our stake is a half unit.